2009;183(6):3720C3730. OSAHS group experienced a significantly lower CD4+/CD8+ ratio (1.24 0.12) than that of control group (1.45 0.11) (P 0.05). The two groups had comparable percentages of CD3+ and CD4+ T lymphocytes (P 0.05). OSAHS group experienced significantly higher serum levels of IL-4, IL-6, IL-10 and IFN- than those of control group (P 0.05), but their IL-2 and TNF- levels were similar (P 0.05). The serum IgA and C3 levels of OSAHS group significantly exceeded those of control group (P 0.05), but their IgG, IgM and C4 levels were similar (P 0.05). Conclusion: Children with OSAHS experienced increased percentage of CD8+ T lymphocytes and decreased CD4+/CD8+ ratio, suggesting this group experienced poor immune function. Increase in humoral immune-related indices IL-4, IL-6, IL-10 and IFN- indicated the occurrence of oxidative stress and systemic inflammatory status. All authors have no conflicts of interest regarding this paper. None. Authors Contribution Designed this study and revised the manuscript. Collected, analyzed clinical data and prepared the manuscript. Recommendations 1. Dyugovskaya L, Lavie P, Lavie L. Lymphocyte activation as a possible measure of atherosclerotic risk in patients with sleep apnea. Ann N Y Acad Sci. 2005;1051(1):340C350. RQ-00203078 [PubMed] [Google Scholar] 2. Mingari MC, Ponte M, Bertone S, Schiavetti F, Vitale C, Bellomo R, et al. HLA class I-specific inhibitory receptors in human T lymphocytes: interleukin 15-induced expression of CD94/NKG2A in superantigen-or alloantigen-activated CD8+T cells. Proc Natl Acad Sci USA. 1998;95(3):1172C1177. [PMC free article] [PubMed] [Google Scholar] 3. Wieckowski EU, Visus C, Szajnik M, Szczepanski MJ, Storkus WJ, Whiteside TL. Tumor-derived microvesicles promote regulatory T cell growth and induce apoptosis in tumor-reactive activated CD8+T lymphocytes. J Immunol. 2009;183(6):3720C3730. doi:10.4049/jimmunol.0900970. [PMC free article] [PubMed] [Google Scholar] 4. Blanco P, Pitard V, Viallard JF, Taupin JL, Pellegrin JL, Moreau JF. Increase in activated CD8+T lymphocytes expressing perforin and granzyme B correlates with disease activity in patients with systemic lupus erythematosus. Arthritis Rheum. 2005;52(1):201C211. [PubMed] [Google Scholar] 5. Kyaw T, Winship A, Tay C, Kanellakis P, Hosseini H, Cao A, et al. Cytotoxic and proinflammatory CD8+T lymphocytes promote development of vulnerable atherosclerotic plaques in apoE-deficient mice. Blood circulation. 2013;127(9):1028C1039. doi:10.1161/CIRCULATIONAHA.112.001347. [PubMed] [Google Scholar] 6. Yu W, Jiang N, Ebert PJ, Kidd RQ-00203078 BA, Mller S, Lund PJ, et al. Clonal deletion prunes but does not eliminate self-specific CD8+T lymphocytes. Immunity. 2015;42(5):929C941. doi:10.1016/j.immuni.2015.05.001. [PMC free article] [PubMed] [Google Scholar] 7. Renrick AN, Thounaojam MC, Dudimah DF, Thomas P, Pellom ST, Uzhachenko RV, et al. Bortezomib enhances expression of effector molecules in antitumor CD8+T lymphocytes by modulating Notch-NF-kB-miR-155 crosstalk. Malignancy Res. 2016;76(14 Suppl):4161C4161. doi:10.1158/1538-7445.AM2016-4161. [Google Scholar] 8. Qin YH, Cai Z, Qiu YR. T cell subsets and NK cell level in patients with obstructive sleep apnea/hypopnea syndrome. Guangdong Med J. 2010;31(5):615C616. [Google Scholar] 9. Clavijo PE, Frauwirth KA. Anergic CD8+T lymphocytes have impaired NF-B activation with defects in p65 phosphorylation and acetylation. J Immunol. RQ-00203078 2012;188(3):1213C1221. doi:10.4049/jimmunol.1100793. [PMC free article] [PubMed] [Google Scholar] 10. Khan MN, Pichichero ME. CD4 T cell memory and antibody responses directed against the pneumococcal histidine triad proteins PhtD and PhtE following nasopharyngeal colonization and immunization Rabbit polyclonal to ZNF264 and their role in protection against pneumococcal colonization in mice. Infect Immun. 2013;81(10):3781C3792. doi:10.1128/IAI.00313-13. [PMC free article] [PubMed] [Google Scholar] 11. Li FJ, Yin MD. Effects of tonsillectomy on serum immune globulins of 35 cases. J Qiqihar Uni Med. 2005;26(12):1454C1454. [Google Scholar] 12. Soudja SMH, Ruiz AL, Marie JC, Lauvau G. Inflammatory monocytes activate memory CD8+T and innate NK lymphocytes impartial of cognate antigen during microbial pathogen invasion. Immunity. 2012;37(3):549C562. doi:10.1016/j.immuni.2012.05.029. [PMC free article] [PubMed] [Google Scholar] 13. Li ZG, Li TP, Ye H, Feng Y, Li DQ. Immune function changes in patients with obstructive sleep apnea hypopnea syndrome. J Southern Med Uni. 2011;31(6):1003C1005. [PubMed] [Google Scholar] 14. Sukumar M, Liu J, Ji Y, Subramanian M, Crompton JG, Yu Z, et al. Inhibiting glycolytic metabolism enhances CD8+T cell memory and antitumor function. J Clin Invest. 2013;123(10):4479C4488. doi:10.1172/JCI69589. [PMC free article] [PubMed] [Google Scholar] 15. Tam CS, Wong M, McBain R, Bailey S, Waters KA. Inflammatory steps in children with.