1 G). process through which the most primitive cells of the hematopoietic system, i.e., hematopoietic stem cells (HSCs), differentiate into mature cells of the myeloid-erythroid and lymphoid lineages (Morrison et al., 1995; Orford and Scadden, 2008; Orkin and Zon, 2008).
To do so, we plated BCR-ABL1+ Lin? c-Kit+ BM cells from mice with CML on E-selectin-coated plates in the presence of vehicle, GMI-1271,22 imatinib23,24 or the combination of GMI-1271 plus imatinib (Figure 2A). BCR-ABL1-specific, Siramesine Hydrochloride cell-intrinsic pathways leading to