Secreted IL-1 was recognized in cell-free supernatants from PBMC or monocytes (enriched by adherence to plastic for 2h followed by washes to remove non-adherent cells) stimulated for 4h or 24h with 20 ng/ml or 1 g/ml of LPS; the human being IL-1 Cytometric Bead Array (CBA, BD Biosciences) was used

Secreted IL-1 was recognized in cell-free supernatants from PBMC or monocytes (enriched by adherence to plastic for 2h followed by washes to remove non-adherent cells) stimulated for 4h or 24h with 20 ng/ml or 1 g/ml of LPS; the human