After three days of exposure to compounds, spheroids had higher baseline CYP activity than monolayers and responded to known CYP inducers and inhibitors as expected. 72 h induction period with known CYP450 inducers/inhibitors. CYP450 activity and viability in the spheroids
Tracy CM, Epstein AE, Darbar D et al
Tracy CM, Epstein AE, Darbar D et al.2012 ACCF/AHA/HRS focused update from the 2008 recommendations for device-based therapy of cardiac tempo abnormalities: a written report from the American University of Cardiology Foundation/American Heart Association Job Power on Practice Recommendations. 489