This work was supported by National Natural Science Foundation of China Grants [31271472; 31322033; 31301110], National Basic Research Program of China [2014CB964703], the Science and Technology Planning Project of Guangdong Province (2015B020228002), and Pearl River Scholar Funded Scheme?(2013)

This work was supported by National Natural Science Foundation of China Grants [31271472; 31322033; 31301110], National Basic Research Program of China [2014CB964703], the Science and Technology Planning Project of Guangdong Province (2015B020228002), and Pearl River Scholar Funded Scheme?(2013). Notes EMBO